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Buster Novelty Company was located at 133 West Front Street. The company manufactured small little knicknacks and trinkets.

The Samuel Horchow Company was located at 40-48 Gallia Street. It manufactured house furniture.

The Daehler Building was a mortuary, sold furniture, Queensware, and carpet. It was located at 82-86 West Second (2nd) Street.

The Scioto Star Fire Brick Company was in Sciotoville, Ohio between the river and the railroad. It was incorporated in 1872 with John Peebles as president. The 13 acre plant made Fire Brick, Clay In-walls and Hearths for blast furnaces, tiles of…

The Portsmouth Shoe Company was located at 127 West Front Street.

The Imperial Rolling Mills was located at 158-160 West Fourth Street. It produced flour, corn meal, and feed.

The Portsmouth Paving Brick Company was located on the west side of Chillicothe Street on the corner of Seventeenth (17th) Street.

The Wait Furniture Company was located on Seventeenth (17th) Street at the southwest corner of Broadway Street.

The York Portland Cement Company was located in New Boston, Ohio.

The Tracy Shoe Company was located at 66-68 West Second (2nd) Street.

The Scioto County Children's Home was located on Grant Street between Hutchins and Grandview Avenue.
The Portsmouth Blade newspaper ran from 1879-1914. The building was located at 119 West Second Street.

The Ohio Stove Company was located at Eleventh (11th) and Chillicothe Streets. It manufactured cooking and heating stoves until the 1950's. It is now known as OSCO Industries, at the same location, and designs and produces gray iron castings for a…