Commercial businesses occupied the space from about 1875-2003.
From about 1875-1928 there were a series of barber shops at the address.
About 1928 the Kroger Grocery & Baking Company built more space and moved in for business. Kroger occupied the…
Private residence. Built about 1909 according the the Scioto County Auditor. Address before 1911 was 121 W 3rd Street. Original owners Augustus & Ottilia Bazler.
First Presbyterian Church, 221 Court Street, corner of 3rd & Court Streets. Dedicated for worship, 1851. The oldest church building in Portsmouth. In 1973 the church building was added to the National Register of Historic Places.
St. Mary's Catholic Church. The church building was completed and dedicated, July 31, 1871. Well known for the matched set of three working tower bells. The bells were cast in Baltimore, Maryland, by the McShane Company in 1895.